Discussion of the design of a randomized trial. "BACKGROUND: Osteoporosis is a major health problem in postmenopausal
women. Evidence suggests the importance of oxidative stress in bone
metabolism and bone loss. Tea consumption may be beneficial to
osteoporosis due to its antioxidant capability. However, lack of
objective data characterizing tea consumption has hindered the precise
evaluation of the association between tea ingestion and bone mineral
density in previous questionnaire-based epidemiological studies. On the
other hand, although published studies suggest that Tai Chi (TC)
exercise can benefit bone health and may reduce oxidative stress, all
studies were conducted using a relatively healthy older population,
instead of a high-risk one such as osteopenic postmenopausal women.
Therefore, this study was designed to test an intervention including
green tea polyphenol (GTP) and TC exercise for feasibility, and to
quantitatively assess their individual and interactive effects on
postmenopausal women with osteopenia. . . . DISCUSSION: We present the rationale, design, and methodology of a
placebo-controlled randomized trial to investigate a new complementary
and alternative medicine strategy featuring a dietary supplement and a
mind-body exercise for alleviating bone loss in osteopenic
postmenopausal women." Abstract: PubMed. Full-text: BMC Musculoskeletal Disorders (2009 Sept 4;10;110).
